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Updated: Sep 19, 2025

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
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PPP2R5D-PP2A全酶的酸酶活性调节了素-α1的液态-液态相分离过程

Abigail Mayer1, Rita Derua2, Elijah Spahn3

  • 1Neuroscience Graduate Program, Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA.

The Journal of biological chemistry
|June 8, 2025
PubMed
概括

素α1的液体-液体相分离 (LLPS) 被素β1和PP2A酸酶抑制. 破坏这些相互作用,特别是S763的酸化,促进LLPS,影响细胞信号传递和潜在的疾病状态,如Houge-Janssens综合征.

关键词:
霍格-詹森综合征 (HSJ) 是一种在光漂白后的光恢复 (FRAP)本质上是无序的蛋白质域.利林-α1α1 的使用.氨酸-β1的使用方法质谱学 (MS) 是一种质谱学.阶段分离的阶段分离.酸化的方法是:光化.蛋白质酸酶2A (PP2A) 是一种

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