抗生素与局部消毒剂对慢性性中耳炎
Karen Head1, Lee Yee Chong1, Mahmood F Bhutta2
1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
The Cochrane database of systematic reviews
|June 8, 2025
概括
与酸相比,局部抗生素,特别是诺,可能会改善慢性性耳中炎 (CSOM) 耳部泄漏的分辨率. 对其他治疗方法的证据有限,并没有充分报告有害影响.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性性耳中炎 (CSOM) 是一种持续的中耳炎和感染,其特征是耳部泄漏 (耳) 和听力损失.
- 治疗方案包括局部或全身抗生素和局部消毒剂,以对抗微生物感染.
研究的目的:
- 对被诊断患有CSOM的个人来说,评估抗生素治疗与消毒剂治疗的比较益处和危害.
- 综合来自随机对照试验 (RCT) 的证据,比较CSOM的不同治疗干预措施.
主要方法:
- 在多个数据库中进行了系统的文献搜索,包括Cochrane ENT Register,CENTRAL,MEDLINE和Embase,直到2022年6月.
- 包括至少为期一周的随访RCT,比较局部/全身抗生素与局部消毒剂在成人和儿童慢性耳部泄漏.
- 主要结局包括耳部泄漏的解决,与健康有关的生活质量和耳部疼痛;次要结局是听力和并发症.
主要成果:
- 局部类抗生素抗生素在一到两周内显示,与酸耳滴相比,耳液分辨率可能增加 (中度确定性证据).
- 局部诺也可能导致耳朵疼痛,不适或刺激比玻利酸更少,可能有更大的听力改善 (低确定性证据).
- 其他比较的证据,例如类与乙酸或波维-类的比较,非常不确定或有限,没有关于生活质量或严重并发症的数据.
结论:
- 局部类抗生素似乎比酸更有效地在两周内解决CSOM中的耳部泄漏.
- 关于其他局部抗生素和消毒剂的疗效的证据有限,因此无法得出明确的结论.
- 需要进一步的研究,因为有害影响没有得到充分报告,其中的局限性包括数据质量和缺乏最新信息.
相关概念视频
01:23Hand hygiene
3.1K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.1K
01:27Combined Effects of Drugs: Synergism
3.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.8K
01:26Tonsillitis II: Management
103
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
103
01:18Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
01:26Urine Studies II: Urine Culture and Sensitivity Test
3
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
3