相关实验视频
Updated: Jun 15, 2025

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
局部抗生素与全身抗生素治疗慢性性中耳炎
Lee Yee Chong1, Karen Head1, Katie E Webster2
1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
与全身抗生素相比,局部类抗生素可能在慢性性耳中炎 (CSOM) 中略有改善耳部泄漏的解决. 然而,证据质量较低,需要更多的研究来确认益处和危害.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性性耳中炎 (CSOM) 是一种持续的中耳感染,导致耳部泄漏和听力损失.
- 抗生素是主要的治疗方法,用于局部或全身治疗感染.
研究的目的:
- 评估局部与全身抗生素治疗CSOM的疗效和安全性.
- 为了比较不同的抗生素类别和施用途径.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 搜索了多个数据库,直到2022年6月,包括Cochrane ENT Register,CENTRAL,MEDLINE和Embase.
- 包括六项具有偏差高风险的研究 (445名参与者),比较局部诺与全身诺,氨基糖化物或基于青素的抗生素.
主要成果:
- 局部诺剂的使用显示,在一到两周内,耳部泄漏的分辨率可能略有增加 (低确定性证据).
- 关于其他比较,长期结果,生活质量,疼痛,听力和严重并发症的证据的确定性非常低或不存在.
- 在大多数研究中没有怀疑耳毒性,但评估方法不明确.
结论:
- 有限,低质量至非常低质量的证据存在,主要来自较旧的研究,阻碍了关于CSOM局部或全身抗生素的最终结论.
- 局部诺可能在实现"耳朵干燥"方面提供了轻微的优势,但这需要进一步调查.
- 没有足够的数据来比较不同类型的抗生素或彻底评估不良影响.
更多相关视频
07:06Endaural Endoscopic Atticoantrotomy Retrograde Mastoidectomy using a Constant Suction Bone-drilling Technique
Published on: May 23, 2021
09:18A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
相关概念视频
Tonsillitis II: Management
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...