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系统性抗生素治疗慢性性中耳炎
Lee Yee Chong1, Karen Head1, Katie E Webster2
1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
系统性抗生素对慢性性中耳炎 (CSOM) 的有效性非常不确定. 有证据表明,当添加到局部治疗时,几乎没有差异,对危害的数据有限.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性性中耳炎 (CSOM) 是一种持续的中耳感染,导致耳部泄漏和听力损失.
- 系统性抗生素是一种常见的治疗方法,但它们在CSOM中的有效性需要严格的评估.
- 本综述是一个更新,是评估CSOM非手术干预的系列的一部分.
研究的目的:
- 评估系统性抗生素与安慰剂,不治疗或其他系统性抗生素对CSOM的有效性.
- 评估结果,包括耳部排泄的分辨率,生活质量,疼痛,听力和并发症.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查,搜索多个数据库,直到2022年6月.
- 包括RCT比较系统性抗生素 (口服/注射) 与安慰剂/不治疗或其他系统性抗生素在CSOM患者.
- 主要结局是耳部泄漏的解决,与健康有关的生活质量和耳部疼痛;次要结局包括听力和并发症.
主要成果:
- 关于单独使用全身抗生素与安慰剂治疗耳部泄漏的有效性,证据非常不确定.
- 当系统性抗生素添加到局部治疗时,排泄分辨率可能几乎没有差异 (低确定性证据).
- 关于生活质量,听力,并发症和伤害的数据在所有比较中都是有限的或非常不确定的.
结论:
- 关于全身抗生素在解决CSOM耳部泄漏方面的有效性,现有的证据有限且不确定.
- 系统性抗生素,单独或作为局部治疗的辅助剂,对排泄分泌有很少或没有明显的益处.
- 需要进一步的研究,特别是不同类抗生素的比较有效性和潜在的危害.
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