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针对慢性性中耳炎的局部抗生素
Christopher G Brennan-Jones1,2, Karen Head3, Lee Yee Chong3
1Ear Health, The Kids Research Institute Australia, The University of Western Australia, Perth, Australia.
局部抗生素可能有助于解决慢性性中耳炎 (CSOM) 的耳部泄漏. 证据有限,但与安慰剂或全身抗生素相比,它们显示出潜力.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性性耳中炎 (CSOM) 是一种持续的中耳感染,导致排泄和听力损失.
- 局部抗生素是一种常见的治疗方法,旨在根除致病微生物.
- 本综述是对CSOM进行非手术干预的最新评估.
研究的目的:
- 评估局部抗生素 (不含类固醇) 对CSOM患者的益处和危害.
- 为了比较局部抗生素与安慰剂或没有干预.
- 为了比较不同的局部抗生素剂.
主要方法:
- 包括随机对照试验 (RCT) 与至少一个星期的随访.
- 干预措施涉及局部抗生素 (滴,粉末,灌) 对于持续排泄的CSOM.
- 结果包括出院分辨率,生活质量,耳朵疼痛,听力和并发症.
主要成果:
- 与安慰剂相比,局部西普罗夫洛克萨可能会增加排泄的分辨率 (非常低的确定性证据).
- 局部抗生素加上全身抗生素可以改善排泄分辨率,而不是单独使用全身抗生素 (低确定性证据).
- 关于不同局部抗生素类别 (例如,诺与氨基糖化物) 之间的比较,证据非常不确定.
结论:
- 由于有限的,低确定性证据,局部抗生素对CSOM的有效性是不确定的.
- 当局抗生素在与安慰剂或全身抗生素一起使用时显示出潜在的益处.
- 需要进一步的研究来澄清比较有效性和安全性.
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