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环境肠病和炎症性肠病不是相互排斥的
Phoebe Hodges1, Mubbunu Malambo2, Wamundila Kawana2
1Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, Lusaka, Zambia; Blizard Institute, Queen Mary University of London, London, United Kingdom.
环境肠病 (EE) 和炎症性肠病 (IBD) 在赞比亚成年人中共存,挑战了关于它们独特起源的假设. 这一发现表明,EE可能会在低收入国家混IBD诊断.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 环境肠病 (Environmental Enteropathy,EE) 是一种小肠病变,与环境因素和反复的肠损伤有关.
- 在新兴工业化国家,炎症性肠病 (IBD) 的发病率正在上升.
- 低收入国家 (LIC) 普遍存在EE,而IBD传统上与发达国家有关,这表明它们可能不会共存.
研究的目的:
- 调查居住在撒哈拉以南非洲,一个低收入地区的成年人中EE和IBD的同时发生情况.
- 评估在被诊断患有IBD的赞比亚个人中EE的患病率.
主要方法:
- 十二指肠活检和肠道和全身炎症的生物标志物被用来评估有IBD和对照的成年赞比亚人的肠病.
- 社会经济地位 (SES) 被分为高和低组进行控制.
- 在IBD病例和对照组之间比较了肠病原体携带率.
主要成果:
- 在所有参与者 (28例IBD病例和59例对照) 中都观察到EE的组织学特征,其中的中位高度与密室深度的比率<2.2.
- 与对照组相比,IBD病例中的肠病原体携带率较低.
- 在高SES和低SES对照组中都存在EE.
结论:
- 在同一个人中IBD和EE的共存可能会使IBD在低收入环境中的评估变得复杂.
- 这一发现可能会挑战这样的解释,即改善环境卫生不是IBD出现的重要因素.
- 在撒哈拉以南非洲等地区,EE应该被认为是IBD诊断中的潜在混因素.
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