在接受瘤手术的患者中,术后运动和术后死亡率:系统性审查和元分析
Christine Ibilibor1, Nathan R Weeldreyer2, Siddhartha S Angadi2
1Division of Urologic Oncology, Department of Urology, University of Virginia, Charlottesville, VA, USA. ci5d@uvahealth.org.
概括
术后运动改善了癌症患者的身体健康,但没有显著影响术后死亡率. 需要更多的研究来确定运动量.
科学领域:
- 在瘤学瘤学.
- 运动生理学 运动生理学
- 外科手术的结果
背景情况:
- 接受手术切除的癌症患者经常经历显著的生理压力.
- 在手术前优化患者的健康状况可能会改善结果并减少并发症.
- 目前正在探索外科手术期间的运动干预措施,以提高康复和生存率.
研究的目的:
- 系统地评估术前运动对瘤患者的生存率和术后死亡率的影响.
- 综合来自随机对照试验的癌症手术中运动干预的证据.
主要方法:
- 2000年至2024年间发表的随机对照试验 (RCT) 的系统性审查.
- 在Embase,PubMed,Web of Science和Cochrane图书馆进行的搜索.
- 评估结果包括无复发生存率,无疾病生存率,癌症特异性生存率,整体生存率和术后死亡率.
主要成果:
- 五项涉及650名瘤患者的RCT (330名在炼组中) 符合纳入标准.
- 术后的运动干预,主要是术前的,涉及步行,骑自行车或慢跑,通常有营养/心理社会支持.
- 虽然心肺呼吸能力有所改善,但仅在一项研究中改善了无疾病生存率,手术后死亡率没有显著差异.
结论:
- 术后运动可以提高癌症患者的身体健康,但缺乏改善术后死亡率的重要证据.
- 有限的样本规模和运动方案的异质性 (类型,持续时间,强度) 限制了最终的结论.
- 未来的大规模,强大的试验是必要的,以确定标准化外科手术前运动对长期瘤结果的影响.
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