用抗微生物光动力疗法治疗简单疹:随机对照试验

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Andreia La Selva¹, Daniella Teixeira Bezerra¹, Rodrigo Melim Zerbinati²

¹Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

|June 9, 2025

概括

抗微生物光动力疗法 (aPDT) 和局部阿西克洛维尔在治愈简单疹病变和防止一年内复发方面表现出类似的疗效. 两种治疗都没有显著影响疼痛,温度或生活质量.

科学领域:

口服药是一种口服药.
皮肤病学皮肤病学
传染性疾病传染性疾病

背景情况:

简单疹病毒 (HSV) 感染很常见,导致重复的疼痛病变.
局部使用的阿西克洛维尔是标准治疗方法,但正在探索替代疗法.
抗微生物光动力疗法 (aPDT) 提供了一种新的方法来管理病毒感染.

研究的目的:

为了比较aPDT与局部阿西克洛维尔治疗简单疹病变的有效性.
评估愈合时间,复发率,病毒载量,疼痛和生活质量的差异.

主要方法:

一个随机对照试验,涉及患者在囊泡或期的简单疹病变.
两个组:一个接受局部阿西克洛维尔加PDT模拟,另一个接受安慰剂膏加PDT.
结果包括病变解决时间,复发,HSV-1量化 (qPCR),疼痛,温度和OHIP-14分数.

主要成果:

一年后,aPDT和阿西克洛维尔组之间没有观察到病变解决时间,复发率,疼痛或局部温度的显著差异.
在阿西克洛维尔组的第三天,观察到唾液中HSV-1病毒载量的暂时增加,但这没有影响临床结果.
口腔健康影响概况问卷 (OHIP-14) 的分数在各组之间是可比的.

结论:

在一年的时间内,aPDT和局部阿西克洛维尔在治疗简单疹病变方面表现出类似的临床疗效.
这两种治疗都有效地解决了病变并预防了病变的复发.
在阿西克洛维尔组观察到的病毒载荷增加与较差的临床结果无关.

关键词:

寒冷的伤口伤口.这是一种简单的疹 (herpes simplex).激光激光激光激光激光甲基烯蓝色是什么意思甲基烯蓝色是什么意思通过光生物调节来进行光生物调节.光动力学疗法是一种光动力学疗法.

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