在马拉维的布兰泰尔进行的阿司匹林预孕早期预防和应对 (CASPER) 试验:双盲集群随机试验
Memory M Ngwira1,2,3, Angela Makris4,5, Renuka Shanmugalingam4,6
1School of Medicine, Western Sydney University, Australia (M.M.N., A.H.).
Hypertension (Dallas, Tex. : 1979)
|June 9, 2025
概括
在马拉维,将低剂量阿司匹林添加到中并没有降低高风险孕妇的孕前率. 这项研究发现,阿司匹林和安慰剂组之间的孕产妇或新生儿结局没有显著差异.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 临床试验 临床试验
背景情况:
- 在全球范围内,孕前是导致孕产妇和新生儿死亡的主要原因.
- 低剂量阿司匹林与联合用于预防马拉维妇女产前的疗效尚不确定.
- 这项研究研究了马拉维布兰泰尔的综合效应.
研究的目的:
- 评估早期低剂量阿司匹林在接受预防产前的妇女中的疗效.
- 评估对产前/产后率和母婴/新生儿二次结果的影响.
主要方法:
- 一个务实的,双盲的,集群随机对照试验.
- 306名高风险妇女从怀孕12-16周到34周接受低剂量阿司匹林 (150毫克/天) 或安慰剂.
- 所有参与者每天接受1克;使用治疗意图分析.
主要成果:
- 在所有分析的女性中,预孕发生在15.8%的女性中,并发生在2.3%的女性中 (n=266).
- 在阿司匹林 (19.3%) 和安慰剂 (12.2%) 组之间的孕前率没有统计学上显著的差异 (aOR 1.16,P=0.781).
- 二次性母亲和新生儿结局也没有显著差异;遵守率为69%.
结论:
- 在接受的高危孕妇中,额外的低剂量阿司匹林并没有降低马拉维的孕前率.
- 在剖腹产率或关键新生儿结局方面没有发现显著差异.
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