异常的微生物群签名在婴儿大肠的症状发展之前
Emmy Van Daele1, Kim Kamphorst2,3, Clara Belzer1
1Laboratory of Microbiology, Wageningen University and Research, Wageningen, the Netherlands.
患有婴儿结肠 (IC) 的婴儿从出生开始就表现出明显的肠道微生物群变化,与健康婴儿不同. 早期的抗生素暴露进一步影响了这些微生物的变化.
科学领域:
- 微生物组研究的研究.
- 儿科卫生健康 儿科卫生健康
- 肠道微生物群的发展
背景情况:
- 婴儿结肠炎 (IC) 影响了大量的婴儿.
- 了解肠道微生物组在IC中的作用对于开发干预措施至关重要.
- INCA队列研究提供了婴儿肠道微生物群的纵向视角.
研究的目的:
- 调查婴儿结肠 (IC) 之前,期间和之后的微生物变化.
- 为了比较患有和没有IC的婴儿的肠道微生物群发育情况.
- 评估早期抗生素暴露对婴儿肠道微生物群的影响,与IC相关.
主要方法:
- 前性队列研究 (INCA) 包括184名满期出生的婴儿,其中30名被诊断患有IC.
- 在从出生到2岁的八个时间点收集便样本.
- 使用16S rRNA基因安普利康序列的肠道微生物组合的分析.
主要成果:
- 患有IC的婴儿在6个月后表现出明显不同的肠道微生物群组成, Pseudomonadota增加,Actinomycetota减少.
- 微生物群的改变在早期发病的IC (≤4周) 中比晚发病的IC (≥4周) 更明显.
- 早期的抗生素暴露与特定的和重叠的属有关,包括增加的Enterococcus和减少的Bifidobacterium.
结论:
- 在患有IC的婴儿中,即使在症状出现之前,肠道微生物群的发展也不同.
- 早期发病的IC与晚期发病的IC相比,显示出更明显的微生物特征.
- 研究结果表明,未来婴儿结肠的预防和治疗策略可能成为潜在的目标.
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