Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a significant...
Hypoglycemia01:26

Hypoglycemia

Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Mitochondria-targeted metformin analogs activate the ER stress-unfolded protein response pathway to drive apoptosis in pancreatic cancer.

Cell death & disease·2026
Same author

A soft diet attenuates exercise-induced increases in cortical bone density and formation in long bones in growing mice.

Scientific reports·2026
Same author

ZO-1 shuttles between apical junctional complexes and podosomes by riding ERK activation waves.

Nature communications·2026
Same author

Two closely related β-1,2-xylosyltransferases differentially impact fungal glycan synthesis.

bioRxiv : the preprint server for biology·2026
Same author

Localized heat induces ERK activation and signal propagation in solid tumors.

Scientific reports·2026
Same author

Metabolic Response to CDK4/6 Inhibition in ER+ Breast Cancer Creates a Therapeutic Vulnerability in Drug-Tolerant Persister Cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

相关实验视频

Updated: Jul 11, 2026

Mass Spectrometric Analysis of Glycosphingolipid Antigens
13:09

Mass Spectrometric Analysis of Glycosphingolipid Antigens

Published on: April 16, 2013

16.5K

丹戈:一个MS数据注释工具,用于糖脂类药物.

Masaaki Matsubara1,2, Mayumi Ishihara1,3, Michael Tiemeyer1

  • 1Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602 USA.

BBA advances
|June 9, 2025
PubMed
概括

我们开发了DANGO,这是一种用于自动注释糖脂的计算工具. 丹戈从质谱数据中分析了甘氨酸和脂质结构,提高了甘氨酸脂质组分析的可靠性和速度.

关键词:
丹戈 (DANGO) 是一种舞蹈.免费软件是免费的软件.葡萄糖脂类药物 葡萄糖脂类药物甘氨基脂是葡萄糖基脂中的一种.质谱测量质量谱测量质谱仪数据处理数据处理.

更多相关视频

Quantitative Analysis of the Cellular Lipidome of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
08:56

Quantitative Analysis of the Cellular Lipidome of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Published on: March 8, 2020

7.3K
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

931

相关实验视频

Last Updated: Jul 11, 2026

Mass Spectrometric Analysis of Glycosphingolipid Antigens
13:09

Mass Spectrometric Analysis of Glycosphingolipid Antigens

Published on: April 16, 2013

16.5K
Quantitative Analysis of the Cellular Lipidome of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
08:56

Quantitative Analysis of the Cellular Lipidome of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Published on: March 8, 2020

7.3K
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

931

科学领域:

  • 格莱科米克斯 (Glycomics) 是一个有趣的药物.
  • 计算生物学 计算生物学
  • 质谱测量质量谱测量

背景情况:

  • 甘氨基脂对真核细胞功能至关重要,在它们的甘氨酸和脂质成分中表现出结构多样性.
  • 现有的计算工具往往侧重于甘氨酸分析,但对动态脂质组成的整合有限.
  • 需要考虑甘氨酸和脂质部分的自动注释工具来进行全面的甘氨酸脂质学研究.

研究的目的:

  • 开发一个自动化的计算工具,DANGO (GlycolipidOmics的数据注释系统),用于注释糖脂的质谱数据.
  • 在一个单一的平台中集成分析甘氨酸和脂质 (胺) 结构.
  • 为了提高 glycosphingolipid 结构注释的可靠性和效率.

主要方法:

  • 开发了DANGO,这是一种扩展GRITS工具箱的计算工具,用于对糖脂组数据集的自动注释.
  • 利用糖脂基数据库,以策划或用户定义的糖和胺集合进行注释.
  • 实施了一种新的过算法,以减少假阳性和提高计算效率.

主要成果:

  • DANGO能够从质谱学数据中自动注释糖和脂质部分在糖类脂质中.
  • 该工具与GRITS工具箱集成,为有组织的数据和元数据注释提供显示程序.
  • 一个新的过算法显著提高了可靠性,并减少了结构注释的计算时间.

结论:

  • 丹戈为糖脂的结构注释提供了一个自动化和高效的解决方案.
  • 该工具通过考虑甘氨酸和脂质多样性来促进全面分析.
  • 丹戈简化了以前劳动密集型的手动注释过程,增强了糖脂组数据的解释.