与肺结核,呼吸道感染 (RTI) 的同时发生的细菌:在资源有限的环境中进行横截面研究
Mpho Magwalivha1, Mpumelelo Casper Rikhotso1, Leonard Owino Kachienga1
1Department of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou 0950, South Africa.
概括
细菌共同感染,特别是非结核性菌根菌 (NTM),在南非结核病 (TB) 患者中很常见,特别是那些感染艾滋病毒的人. 这些共同感染使治疗复杂化,并强调需要综合公共卫生战略.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 细菌共同感染对结核病 (TB) 治疗结果产生重大影响,特别是在资源有限的环境中.
- 结核病共感染的错误诊断加快了疾病的进展,并导致耐药性,增加死亡率.
- 这项研究调查了南非农村地区肺结核患者的细菌共感染.
研究的目的:
- 在肺结核患者中识别和表征细菌共同感染.
- 评估非结核菌 (NTM) 和其他细菌物种的流行率.
- 探索共同感染,艾滋病毒状况和社会人口因素之间的关联.
主要方法:
- 从正在接受治疗的结核病患者收集了100个唾液和100个血液样本.
- 使用基于PCR的试验 (AnyplexTM MTB/NTMe,AllplexTM MTB/MDR/XDRe,AllplexTM Bacteria) 进行病原体检测和药物耐药性分析.
- 使用血液检测套件确定艾滋病毒状态.
主要成果:
- 在67%的参与者中检测到非结核性真菌菌 (NTM),其次是Aeromonas spp. (19%),Vibrio spp. 这种病毒. (2%) 和大肠杆菌 (2%).
- 在2%的队列中发现了耐多药性Mycobacterium结核病 (MTB) 菌株.
- 虽然在统计学上并不显著,但NTM和Aeromonas spp. 在艾滋病毒阳性个体中更为普遍,在艾滋病毒阳性参与者中有36例NTM病例.
结论:
- 年龄,社会经济地位和性别影响了对结核病,艾滋病毒和细菌共感染的易感性.
- 这些共同感染会使治疗结果复杂化,原因是结核病和艾滋病毒之间的复杂相互作用.
- 公共卫生干预必须考虑社会人口因素,以减少结核病-艾滋病毒联合感染和相关细菌感染的负担.
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