在印度东部的低社会经济阶级和高社会经济阶级中,格兰阴性细菌的卡巴耐药性不同
Debarghya Chakraborty1, Triparna Roy2,3, Priyankar Gangopadhyay1
1Internal Medicine, Princess Royal University Hospital, London, GBR.
Cureus
|June 9, 2025
概括
抗生素耐药性是一个重大的全球健康问题,特别是在东南亚. 这项研究发现,印度较高社会经济群体与较低社会经济群体之间的卡巴耐药性没有显著差异,这表明这个问题超越了经济界限.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 抗生素耐药性是一个日益增长的全球健康威胁,东南亚是主要的中心.
- 社会经济因素可能会影响抗生素耐药性的传播和流行.
研究的目的:
- 在临床样本中评估格拉姆阴性细菌 (GNB) 和格拉姆阴性可可巴菌 (GNCB) 的碳烯胺耐药性 (CR).
- 为了比较印度加尔各答的不同社会经济群体之间的CR患病率.
主要方法:
- 从2023年10月到2024年1月,对248种临床培养结果 (尿液,唾液,血液,伤口,液) 的回顾性分析.
- 较高社会经济阶层和较低社会经济阶层的患者之间的CR率的比较,根据食 ration卡状态确定.
- 对常见分离物的耐药性模式的分析,包括*Acinetobacter baumannii*,*Escherichia coli*,*Klebsiella pneumoniae*和*Pseudomonas aeruginosa*.
主要成果:
- 在所有样本类型中,GNB的患病率更高,而在血液和液中,GNBCB更常见.
- 在GNB中观察到显著的抗生素耐药性对伊米 (27.5%) 和美罗 (28.1%).
- 在较高 (41.7%) 和较低 (45.3%) 的社会经济群体之间,没有发现对卡巴胺耐药性的统计学上显著差异.
结论:
- 克拉姆阴性细菌的碳烯耐药性在印度加尔各答普遍存在,并且在社会经济群体之间没有显著差异.
- 滥用抗生素,过度处方和管理不当是耐药性的关键驱动因素,影响所有社会经济层面.
- 专注于医疗保健提供者教育,公众意识和改善卫生条件的干预措施对于打击抗生素耐药性至关重要.
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