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Updated: Aug 1, 2026

In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
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巨细胞灭会调解新生儿的高氧诱导的炎症性肺损伤

Zikun Tu1,2, Haiyan Guo1,3, Yajing Gao1,3

  • 1Department of Critical Care Medicine, Children's Hospital of Fudan University, National Children's Medical Center, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Frontiers in immunology
|June 9, 2025
PubMed
概括

在新生小鼠中,高氧会通过NLRP3炎症酶激活和热致死诱导肺损伤. 卡斯帕酶-1 抑制剂VX-765通过抑制热致死,改善肺部发育来保护这种损伤.

关键词:
在VX-76565中使用.支气管肺功能障碍症 (BPD) 是一种疾病.气体皮质D (GSDMD) 是一种天然气皮质.巨细胞是一个巨细胞.热致灭 (pyroptosis) 是一种致的过程.

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