第一个出生队列:设计和基线特征
Jonathan I Witonsky1, Jennifer R Elhawary2, Celeste Eng2
1Department of Pediatrics, University of California, San Francisco, Calif.
概括
在PRIMERO研究中的波多黎各儿童正在监测生命早期的呼吸系统疾病 (RIs) 和喘发育. 这项研究调查了高风险人群中RI和喘之间的联系.
科学领域:
- 儿科呼吸系统医学 儿科呼吸系统医学
- 环境流行病学环境流行病学
- 传染性疾病 传染性疾病
背景情况:
- 早期的呼吸系统疾病 (RIs) 与儿童喘有关,但因果关系尚不清楚.
- 波多黎各儿童患上RI和喘的负担很高,这使得他们成为这项研究的关键人口.
- 调查RI是否会使儿童易患喘,或者它们是否是同时发生的疾病至关重要.
研究的目的:
- 描述波多黎各呼吸系统结果的婴儿元基因组和流行病学研究 (PRIMERO) 出生队列的设计和基线特征.
- 检查呼吸道病毒在RI和喘发展中的作用.
- 了解病毒相关喘的早期决定因素和机制.
主要方法:
- 在波多黎各卡古阿斯的一家特定医院招募孕妇.
- 通过出生问卷和年度随访收集临床,社会和环境数据.
- 收集各种生物样本,包括母体血液,婴儿带血,2岁婴儿血液和5年多的鼻气道上皮样本.
主要成果:
- 在2020年2月至2023年6月期间,有2100个母婴二入学.
- 参与者保留率很高 (2,069人活跃),生物样本和参观参与度强.
- 监测发现了6076个RIs,其中38.4%影响了下呼吸道.
结论:
- PRIMERO出生队列为研究与病毒相关的喘发展提供了一个独特的数据集.
- 有关于病毒暴露,呼吸道结果和呼吸道分子表型的全面数据.
- 这项研究很好地解决了有关高风险人群中喘早期决定因素的关键问题.
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