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Updated: Jun 12, 2025

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
11:13

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Published on: July 12, 2018

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针对膜蛋白的有针对性的降解的GPC3介导的溶酶体向化实体 (GLTACs)

Yuxin Fang1, Yaojin Zhu2, Wei Wang1

  • 1Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai 200433, China.

Acta pharmaceutica Sinica. B
|June 9, 2025
PubMed
概括

我们开发了 glypican-3 (GPC3) 介导的 lysosome-targeting chimeras (GLTACs) 来降解瘤膜蛋白质. GLTACs通过降解PD-L1.1等蛋白质,显示出向癌症治疗的潜力.

关键词:
在Glypican-3中使用.Lysosomal 降解 溶酶体的降解膜蛋白是一种膜蛋白质.在PD-L1中.有针对性的蛋白质降解降解.

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