精神压力期间冠状动脉血管功能障碍的女性的副交感反应与非心脏胸痛和参考对照对照的女性相比
Puja K Mehta1,2, Shafa-At A Sheikh3, Esha K Dave1
1Emory Women's Heart Center and Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA, USA.
概括
与其他组相比,患有冠状动脉血管功能障碍 (CVaD) 的女性在精神压力期间表现出降低的副交感活动. 这表明异常的自主反应可能在CVaD病理生理学中发挥作用.
科学领域:
- 心脏病学 心脏病学
- 自主神经系统研究 自主神经系统研究
- 心理生理学 心理生理学
背景情况:
- 冠状动脉功能障碍 (CVaD) 可以在没有阻塞性冠状动脉疾病的情况下引起缺血.
- 对精神压力的异常自主反应被假设为CVaD的关键机制.
- 这项研究比较了患有CVaD,非心脏性胸痛 (NCCP) 和参考对照 (RC) 的女性的自主反应.
研究的目的:
- 为了研究自主神经系统在精神压力期间的反应在患有CVaD的女性中所起的作用.
- 为了比较心率变化 (HRV) 在精神压力之间的CVaD,NCCP和RC组.
- 确定改变的自主反应是否是CVaD中显著的病理生理机制.
主要方法:
- 70名女性 (35名CVaD,19名NCCP,16名RC) 接受了心理压力测试 (算术,愤怒回忆).
- 频率域心率变化 (HRV) 在基线和压力期间被测量.
- 使用ANOVA分析了高频 (HF) 功率 (副交感测量) 和LF/HF比率 (交感测量).
主要成果:
- CVaD组比NCCP组年长,但与RC组年龄相匹配.
- 在精神压力 (恐惧回忆和算术) 期间,CVaD组与NCCP和RC组相比,HF HRV显著降低.
- 两组之间LF/HF比率没有发现显著差异.
结论:
- 与NCCP和RC女性相比,患有CVaD的女性表现出更大的压力诱导的阴道抽缩 (降低的副交感活动).
- 改变的自主反应,特别是压力下降的阴道音调,与CVaD的病理生理学有关.
- 需要进一步的研究来探索这些改变的自主反应作为CVaD中的机制.
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