开发和初步使用新的炎症性肠病临床数据库,整合东方和西方临床特征
Jingshuang Yan1,2,3, Rongrong Ren1, Ruqi Chang1,2
1Department of Gastroenterology and Hepatology The First Medical Center, Chinese PLA General Hospital Beijing China.
Chronic diseases and translational medicine
|June 9, 2025
概括
一个新的301炎性肠病 (IBD) 数据库整合了东方和西方的数据,以应对研究挑战. 分析显示了性结肠炎和克罗恩病住院患者的明显临床特征,突出了趋势和治疗模式.
科学领域:
- 胃肠病学 胃肠病学
- 临床信息学 临床信息学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 发病率的上升带来了重大挑战.
- 区域IBD数据库之间的不一致性阻碍了国际研究合作.
- 统一,全面的IBD数据库对于流行病学研究和临床管理至关重要.
研究的目的:
- 开发和应用301 IBD数据库,整合来自宾夕法尼亚州IBD数据库 (美国) 和中国人民解放军总医院 (PLAGH) 临床实践的数据.
- 通过使用新开发的数据库,分析从2008年到2023年在PLAGH的IBD住院患者的临床数据.
- 为了比较东部和西部IBD的临床特征,并确定趋势.
主要方法:
- 开发301 IBD数据库,包含6个部分的490个项目,重点关注住院患者数据,生化指标,机会性感染和性结肠炎 (UC) 相关并发症.
- 从宾夕法尼亚州IBD数据库和PLAGH指南中整合IBD临床特征.
- 应用数据库用于PLAGH的IBD住院患者的单中心分析.
主要成果:
- 301 IBD数据库包括IBD住院患者的人口,临床和治疗数据.
- 患有IBD的住院率从2008年的2.35%增加到2023年的3.94%.
- 性结肠炎 (UC) 住院患者显示男性占主导地位 (62.5%),广泛的病变 (55.1%),低生物使用 (4.1%),高UC-CRC发病率 (3.0%).
- 克罗恩氏病 (CD) 的住院患者呈现出男性占主导地位 (68.39%),早期发病 (35.43±14.75岁),以及高的手术率 (25.81%).
结论:
- 301 IBD数据库通过整合东方和西方数据,成为IBD临床研究的宝贵工具.
- 该数据库有助于分析IBD患者群体的不同临床特征和趋势.
- 未来利用该数据库的国际多中心合作预计将进一步推进IBD研究.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
323
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
323
01:30Inflammatory Bowel Disease II: Crohn's Disease
194
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
194
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
148
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
148
01:17Chronic Bowel Disorders: Introduction
403
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
403
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
146
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
146
01:29Inflammatory Bowel Disease IV: Pharmacological Management
118
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
118