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从可变性到稳定性:IBD人类肠道微生物组研究中的网络属性的敏感性

Theresa Geese¹, Astrid Dempfle¹

¹Institute of Medical Informatics and Statistics, Kiel University and University Hospital Schleswig-Holstein, Kiel, Germany.

Computational and structural biotechnology journal

|June 9, 2025

概括

在炎症性肠病 (IBD) 中,肠道微生物组的网络分析揭示了对丰度变化的敏感性. 这些发现强调了在解释IBD微生物组网络数据时需要谨慎,因为IBD微生物组的变异性.

科学领域:

微生物学微生物学
生物信息学是一种生物信息学.
胃肠病学胃肠病学

背景情况:

肠道微生物组在炎症性肠病 (IBD) 中发挥着关键作用.
网络分析是了解肠道微生物群复杂性的有希望的工具.
评估微生物丰富度变化的网络特性影响对于可靠的IBD研究至关重要.

研究的目的:

评估肠道微生物群网络特性对IBD微生物丰度变化的敏感性.
为了确定网络属性是否准确地反映IBD微生物组,或者是否过度受到变异性的影响.
评估实验室和个人内变异对IBD网络分析的影响.

主要方法:

使用来自KINDRED和PRISM队列的数据构建了微生物网络,包括IBD患者和健康对照.
基因被用作节点,显著的对应关系代表了边缘.
与疾病相关的和与疾病无关的属的丰富性有所变化 (±30%),以评估网络属性变化.

主要成果:

IBD网络属性对丰度变化表现出敏感性,小变化和大变化的效果相似.
当地网络属性显示,在消耗了与疾病相关的一般性时,大小依赖的变化高达50%.
在IBD病例中,全球网络属性保持相对稳定 (<10%的变化),表明稳定的dysbiosis.

结论:

基于网络的微生物组分析需要谨慎,因为丰度变化的重大影响.
微生物组数据的变化可能会影响网络分析结果的可重复性.
观察到的IBD失生症的稳定性可能对开发微生物组向治疗提出挑战.

关键词:

我们的肠道微生物组.炎症性肠病是一种炎症性肠病.网络分析网络分析网络属性网络属性敏感度敏感度敏感度不同的微生物群丰富度变化.

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