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疾病治疗中的巨细胞两极分化:从阿斯特拉加索酸IV和环氨基醇的见解

Bei-Bei Xiong¹, Yu-Mei Zhuo², Huan Wang²

¹Department of Oncology, The First People's Hospital of Shuangliu District, Chengdu, China.

Frontiers in pharmacology

|June 9, 2025

概括

来自Astragalus membranaceus的阿斯特拉加索酸IV (AS-IV) 和环烯醇 (CAG) 调节巨细胞极化,准关键通路以抑制炎症并促进愈合. 这些天然化合物有望治疗各种疾病,包括癌症和自身免疫性疾病.

科学领域:

免疫学和药理学
自然产品化学自然产品化学
疾病的病原发生疾病的病原发生

背景情况:

巨细胞两极分化是许多疾病的核心,包括炎症,自身免疫,代谢障碍和癌症.
尽管有进展,精确调节巨细胞两极分化仍然是一个治疗挑战.
自然产品为调节巨细胞行为提供了有希望的策略.

研究的目的:

系统地审查阿斯特拉加索酸IV (AS-IV) 和环烯醇 (CAG) 调节巨分极的机制.
探索AS-IV和CAG在各种疾病模型中的治疗潜力.
确定未来的方向,以加强AS-IV和CAG的临床应用.

主要方法:

从PubMed,Google Scholar和SciFinder中对2013年至2025年间发表的研究进行系统的文献综述.
分析AS-IV和CAG针对的信号通路,包括TLR4/NF-κB,PI3K-AKT,AMPK和PPARγ.
评估AS-IV和CAG对巨细胞表型 (M1与M2) 和相关治疗结果的影响.

主要成果:

AS-IV和CAG有效调节巨细胞极化,转向抗炎M2表型.
这些化合物准了参与免疫反应和炎症的关键信号通路.
证据支持它们在炎症性疾病,自身免疫性疾病,代谢综合征和癌症中的治疗潜力.

结论:

通过调节巨细胞极化,AS-IV和CAG显示出作为治疗剂的巨大潜力.
纳米技术的整合可以提高它们的生物可用性和有针对性的交付.
专注于基因编辑,药物设计和纳米技术的未来研究对于临床转化和优化疗效至关重要.

关键词:

阿斯特拉加洛西德IV 这是一种循环氨醇.巨细胞的两极分化纳米药物输送纳米药物输送自然产品是自然产品的产品.

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