胃的结环细胞癌与状膜溢出:横向偏移和液体组成的变化
Akina Nigi1, Toshikazu Kumasa1, Keisuke Iwamoto1
1Department of Respiratory Medicine, Japanese Red Cross Ise Hospital, Ise, Japan.
Case reports in oncology
|June 9, 2025
概括
这一案例突出显示了具有侵略性的胃癌,呈现为胆胸部,具有独特的液体变化和进展,尽管治疗. 早期的CLDN18.2测试可能为标签环细胞癌提供向治疗选择.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 肺部病理学 肺部病理学
背景情况:
- 胆胸是一种罕见的恶性肺溢症并发症,胃癌是罕见的原因.
- 标签环细胞癌 (SRCC) 是一种具有攻击性的胃癌亚型,以淋巴系统入侵和早期转移而闻名.
研究的目的:
- 报告一个独特的胃癌病例,呈现双边胆胸部和正在演变的肺部液体特征.
- 强调早期分子分析的潜在作用,包括CLDN18.2,用于指导侵袭性胃癌的治疗.
主要方法:
- 一个66岁妇女的病例介绍,她患有双侧胸,最初怀疑是淋巴瘤.
- 细胞学证实SRCC尽管最初的内镜发现.
- 用化疗 (capecitabine加上oxaliplatin) 和免疫疗法 (nivolumab) 进行治疗.
- 对CLDN18.2表达的遗传分析.
主要成果:
- 患者经历了双边胆胸,单边复发,从胆液转变为非胆液,并增加了CEA水平.
- 疾病进展发生了尽管治疗,导致复发和死亡在4个月内.
- 基因检测显示CLDN18.2的阳性.
结论:
- 这一案例说明了在胃癌中发生的多发性溢液特征的罕见进展.
- 淋巴阻塞和瘤透可能发生动态变化.
- 早期的CLDN18.2测试可以确定晚期胃癌中向治疗的候选人.
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