在糖尿病前期增加结直肠癌风险:元分析
Na Wang1, Tian-Yi Zhao1, Xiao Ma2
1Physical Examination Center, China-Japan Friendship Hospital, Beijing 100029, China.
World journal of diabetes
|June 9, 2025
概括
糖尿病前期患者患有结直肠癌 (CRC) 的风险增加. 这一元分析证实,与正常血糖水平的人相比,糖尿病前期患者患CRC的可能性更高.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 关于糖尿病前期和结直肠癌 (CRC) 之间的关联存在相互矛盾的证据.
- 糖尿病前期是一个日益严重的公共卫生问题,可能与各种慢性疾病有关.
研究的目的:
- 系统地评估患有糖尿病前期患者和患有正常血糖的人群中CRC的发生率.
- 进行元分析以整合相关队列研究的发现.
主要方法:
- 在MEDLINE,Web of Science和EMBASE进行了系统的文献搜索.
- 11个队列研究,包括4,996,352名参与者被纳入了元分析.
- 使用随机效应模型将数据结合起来,并进行子组分析以探索异质性.
主要成果:
- 患有糖尿病前期的人患CRC的可能性显著增加 (RR = 1.18,P < 0.001).
- 这种关联在各种研究设计和人口统计学方面是一致的,统计异质性较低 (I2 = 27%).
- 亚组分析显示,当糖尿病前期由禁食葡萄糖受损或HbA1c升高来定义时,这种联系最为强烈.
结论:
- 前糖尿病与患结直肠癌的风险增加有关.
- 这些发现强调了管理糖尿病前期的重要性,以潜在地减少CRC发病率.
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