相关实验视频

Updated: Jun 12, 2025

Effects of Different Connection Modes of Electroacupuncture on Electrocardiogram and Nerve Discharge in Rats

Effects of Different Connection Modes of Electroacupuncture on Electrocardiogram and Nerve Discharge in Rats

Published on: January 3, 2025

电 ?? 在调节胰腺功能和脂肪组织扩张方面的神经生理机制

Yun Liu¹, Zhi Yu¹, Xuan Wang²

¹Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.

World journal of diabetes

|June 9, 2025

概括

在特定的针点,特别是ST25的电针 (EA) 通过激活TRPV1-CGRP通路来改善葡萄脂代谢,有利于小岛贝塔细胞并降低与肥胖相关的胰岛素抵抗力.

科学领域:

代谢生理学代谢生理学
神经内分泌学神经内分泌学
传统中国医药传统中国医药

背景情况:

电针 (EA) 在通过感官神经通路调节葡萄脂代谢方面表现有前途.
周胰腺脂肪组织 (PAT) 的扩张与肥胖和2型糖尿病 (T2DM) 的进展有关.
EA对胰腺的影响,特别是关于PAT相互作用,需要进行详细的研究.

研究的目的:

在高脂肪饮食 (HFD) 诱导的老鼠模型中研究EA对胰腺葡萄脂代谢的影响.
阐明特定的神经通路调解EA对胰腺和PAT功能的影响.
为了确定改善甘油脂代谢的最佳针点.

主要方法:

在胰腺和PAT中评估蛋白质表达 (NGF,TRPV1,胰岛素).
使用高脂肪饮食 (HFD) 鼠标模型和TRPV1淘汰小鼠.
研究了EA在ST25,LI11和ST37针点上的影响.
研究了TRPV1-CGRP-岛屿β细胞通路和PAT炎症.

主要成果:

在ST25的EA显著降低了HFD诱导的肥胖和胰岛素抵抗 (IR),表现优于LI11和ST37.
在ST25的EA激活了TRPV1-CGRP-岛屿β细胞通路,减轻了葡萄脂代谢压力.
TRPV1 感官附带沉默取消了 EA 的益处;TRPV1 淘汰的小鼠显示减少了 PAT 炎症和恢复了岛屿功能.
在LI11和ST37的EA表现出抗炎作用,并改善了IR.

结论:

周胰腺脂肪组织 (PAT) 在通过免疫代谢途径在肥胖引起的2型糖尿病 (T2DM) 进展中起着至关重要的作用.
在ST25的电针 (EA) 通过TRPV1-CGRP-岛屿β细胞轴有效调节葡萄脂代谢.
通过调节神经脂肪-胰腺相互作用,EA证明了对代谢障碍的治疗潜力.

关键词:

电 ?? 疗法是一种电疗法.胰岛素耐药性胰岛素耐药性是一种胰腺β细胞是胰腺β细胞.周围胰腺脂肪组织感觉神经是一种神经.暂时的受体潜力瓦尼洛伊德1受体

更多相关视频

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

相关概念视频

Regulation of Food Intake

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...