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核因子红色素2相关因子2在糖尿病足的负压伤疗法中的作用

Hao-Jie Sun¹, Shan-Wen Si², Ya-Mei Ma³

¹Department of Endocrinology, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province, China.

World journal of diabetes

|June 9, 2025

概括

负压伤疗法 (NPWT) 通过减少氧化应激和炎症,显著改善了糖尿病足 (DFU) 的愈合. 这种疗法激活Nrf2通路,增强抗氧化防御和促进血管生成,以改善伤口恢复.

科学领域:

伤口治愈研究研究伤口治愈研究
生物医学工程生物医学工程
细胞生物学细胞生物学

背景情况:

糖尿病足 (DFU) 是一个重大的临床挑战.
负压伤疗法 (NPWT) 对DFU治疗有希望,但其机制尚未完全理解.
在DFU的NPWT中Nrf2/Keap1通路和血管生成的作用需要进一步调查.

研究的目的:

阐明NPWT促进DFU愈合的潜在机制.
研究NPWT对Nrf2/Keap1信号通路和血管生成标记物的影响.
评估NPWT对DFU中氧化应激和炎症标志物的影响.

主要方法:

一项涉及40名患有DFU的住院患者的比较研究,分为对照组和NPWT组.
对Nrf2,Keap1,炎症标志物 (ESR,PCT,IL-6,TNF-α),血管新生标志物 (VEGF,b-FGF,CD31) 和氧化应激标志物 (MDA,SOD,CAT,T-AOC) 的分析.
在治疗前和治疗后7天进行测量,并使用曼-惠特尼U测试进行统计分析.

主要成果:

与对照组相比,NPWT显著改善了DFU伤口愈合.
NPWT可以降低炎症标志物 (ESR,PCT,IL-6,TNF-α) 和氧化应激 (MDA).
NPWT增加了血管新生标志物 (CD31,VEGF,b-FGF) 并激活了Nrf2通路,提高了抗氧化能力 (SOD,CAT,T-AOC).

结论:

通过减轻氧化应激和炎症,NPWT促进DFU的愈合.
激活Nrf2通路和增强血管生成是NPWT在DFU有效性的关键机制.
NPWT代表了一种有前途的治疗策略,用于治疗糖尿病足.

关键词:

糖尿病足部糖尿病足部治愈治愈治愈治愈凯尔奇类的化相关蛋白 1 1 负压伤口治疗疗法负压伤口治疗核因子红色素2相关因子2的核因子.

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