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Updated: Jun 12, 2025

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing
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VenusMutHub:对小规模实验数据上的蛋白质突变效应预测者的系统评估.

Liang Zhang1,2, Hua Pang3,4, Chenghao Zhang5

  • 1School of Physics and Astronomy & Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai National Centre for Applied Mathematics (SJTU Center), MOE-LSC, Shanghai 200240, China.

Acta pharmaceutica Sinica. B
|June 9, 2025
PubMed
概括

蛋白质工程的计算模型通常使用有限的深度突变扫描 (DMS) 数据进行评估. VenusMutHub在905个小规模数据集上对23个模型进行了基准测试,为预测突变效应提供了更好的现实应用性.

关键词:
活动活动活动.一个基准的基准.结合性亲缘关系是一种结合性亲缘关系.突变效应预测和预测蛋白质工程是一种蛋白质工程.选择性的选择性小规模的实验数据.稳定的稳定性 稳定的稳定性

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相关概念视频

Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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