2010年至2020年芬兰的巨细胞动脉炎:发病率,发展的诊断方法和疾病表现
Lauri Kivitalo1,2, Kirsi Taimen3,4, Tuulikki Sokka-Isler5,6
1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Rheumatology advances in practice
|June 9, 2025
概括
芬兰的巨细胞动脉炎 (GCA) 发病率上升,通过先进的成像诊断证实了更多诊断. 随着时间的推移,大型船GCA (LV-GCA) 也越来越频繁地被发现.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 内部医学 内部医学
背景情况:
- 巨细胞动脉炎 (GCA) 是一种系统性血管炎,影响中大动脉.
- 了解GCA发病率和诊断的时间趋势对于公共卫生和临床管理至关重要.
- 之前的研究表明,GCA流行病学的地理和时间变化.
研究的目的:
- 调查2010年至2020年芬兰每年发生的GCA.
- 分析诊断方法的变化,包括成像和活检确认.
- 描述临床表现和表型,特别是头骨与大血管 (LV) - GCA,随着时间的推移.
主要方法:
- 从2010年到2020年,在芬兰四个医疗保健区对新诊断的GCA患者进行了回顾性分析.
- 审查医疗记录,以收集有关发病率,诊断方式和患者表型的数据.
- 统计分析用于比较两个时间段 (2010-2015年和2016-2020年) 之间的诊断方法和发病率.
主要成果:
- 总共有602名GCA患者被确定. 发病率为9.0例/100,000人 (≥50岁),与2010-2015相比,2016-2020年有显著增加.
- 确定的诊断 (成像或活检) 的比例从64.7%上升到82.2%,成像的使用增加,动脉活检的使用减少.
- 大型船舶GCA (LV-GCA) 识别在两个时期之间从19.3%增加到34.0%.
结论:
- 芬兰的GCA发病率有所增加,这可能受到先进成像技术的广泛采用的影响.
- 对GCA的诊断确认率有所改善,反映了医学成像技术的进步.
- 大型船舶GCA (LV-GCA) 病例的确诊量显著增加.
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