周围脂肪作为代谢综合征的潜在标记物和治疗点:来自多中心随机对照试验的见解
Yang Hua1, Meng-Huan Li1,2, Yu-Xuan Lou1
1Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Frontiers in endocrinology
|June 9, 2025
概括
周周脂肪体积 (PrFV) 的增加与中国成年人代谢综合征 (MetS) 的风险增加有关. 这种内脏脂肪可能是管理MetS的关键指标和潜在目标.
科学领域:
- 内分泌学 在内分泌学.
- 心血管疾病 心血管疾病
- 代谢健康 代谢健康
背景情况:
- 代谢综合征 (MetS) 是一种代谢异常的集群.
- 围周围的脂肪,围绕脏,具有独特的特点.
- 在中国成年人中,围膜脂肪体积 (PrFV) 和MetS之间的关联需要研究.
研究的目的:
- 检查中国成年人中PrFV和MetS之间的关系.
- 为了确定PrFV是否可以预测MetS.
- 将PrFV的预测值与其他脂肪库进行比较.
主要方法:
- 一个随机临床试验的后期分析,涉及100名中国成年人.
- 用超声波测量PrFV;用MRI测量其他脂肪体积.
- 用于评估关联的相关性和多变量回归分析.
主要成果:
- PrFV与总胆固醇,甘油三,LDL-C,心动血压,BMI,腰围和尿酸正相关.
- 最高的PrFV三位数与4.48倍的MetS风险增加有关.
- PrFV显示,对MetS的预测值高于皮下和内脏脂肪体积.
结论:
- 升高的PrFV与中国成年人MetS风险增加有显著关联.
- 周围脂肪可以作为一个有价值的代孕标志物,用于MetS.
- 针对周围脏脂肪可能是MetS的潜在治疗策略.
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