在老年人群中具有死亡率和主要不良心血管事件的代谢综合征
Shailendra Kumar Karn1, Fang Zhao2, Yawei Xu1
1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Frontiers in endocrinology
|June 9, 2025
概括
代谢综合征 (MS) 独立地预测了老年人的主要不良心血管事件 (MACE). 中心肥胖,高血压和高血糖是关键的危险因素,突出了对老年人早期多发性硬化症治疗的需要.
科学领域:
- 老年学是指老年学的学科.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是全球领先的健康问题.
- 代谢综合征 (MS) 显著导致主要不良心血管事件 (MACE).
- 关于老年人群中多发性硬化和长期心血管结果的研究有限.
研究的目的:
- 调查MS对MACE在老年人群中的影响.
- 为了确定预测老年人MACE的特定MS组件.
主要方法:
- 对3352名老年居民进行前性队列研究 (上海北部研究).
- 平均随访时间为5.6年.
- 根据修改的NCEP ATP III标准定义的MS;MACE包括非致命的MI,中风,心血管死亡和全因死亡率. 使用了卡普兰-梅尔和物流回归分析.
主要成果:
- 在队列中,多发性硬化症的患病率为44.2%.
- 在患有多发性硬化症 (12.69%) 和没有多发性硬化症 (9.30%) 的参与者中,MACE发病率较高,p=0.02.
- 多发性硬化是MACE的独立风险因素 (HR 1.471,p=0.001);中心肥胖,高血压和高血糖组合显示出最强的预测 (HR 3.001,p<0.001).
结论:
- 代谢综合征是老年人MACE的独立预测因子.
- 中心肥胖,高血压和高血糖是MS中MACE的关键风险因素.
- 早期识别和治疗MS对于降低心血管风险和改善老年人的结果至关重要.
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