与骨矿物质密度低和儿童骨质疏松症相关的危险因素:一项横截面分析研究
Berta Magallares1,2,3, Dacia Cerdá4, Jocelyn Betancourt3,5
1Department of Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Frontiers in endocrinology
|June 9, 2025
概括
在成长中的儿童中,确定低骨质量 (LBMca) 和儿童骨质疏松症 (cOP) 的危险因素至关重要. 一项研究发现10.5%的有风险儿童患有LBMca,4.8%患有cOP,久坐不动的生活方式是关键因素.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 儿童骨健康 儿童骨健康
- 骨的发育 骨的发育
背景情况:
- 早期识别慢性年龄低骨质量 (LBMca) 和儿童骨质疏松症 (cOP) 的危险因素对于缓解长期骨并发症在成长中的儿童至关重要.
- 儿童骨质疏松症 (cOP) 是由LBMca (BMD Z-score ≤2) 定义的,具有骨折史或脊椎脆弱性骨折的存在.
研究的目的:
- 识别和分析与儿童患者低骨质量和儿童骨质疏松症相关的风险因素.
- 为了确定LBMca和cOP在患有已确定危险因素的儿童队列中的患病率.
主要方法:
- 包括21岁以下的患有LBMca风险因素的患者 (例如,吸收不良,慢性疾病,某些药物).
- 收集关于骨折史和身体活动水平的数据.
- 利用双能X射线吸收仪 (DXA) 来评估脊椎和全身骨矿物质密度 (BMD),并进行脊椎形态测量. 分析了使用年龄调整线性回归的关联.
主要成果:
- 研究了103名患者 (平均年龄9.8岁),其中96.1%具有多种危险因素.
- 在LBMca的患病率为10.5%,在cOP的患病率为4.8%.
- 脊椎BMD与男性性别正相关. 全身和总体减去头部BMD显示与久坐的生活方式,骨折史和当前类固醇治疗有负面关联.
结论:
- 患有风险的儿童群体经常存在多种风险因素,包括身体不活动.
- 具有危险因素的儿童中有很大比例表现出LBMca (10.5%) 或cOP (4.8%).
- 需要进行长度研究,以澄清年龄,性别,体力活动,种族和维生素D状况等因素对儿科骨健康的长期影响.
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