心理弹性与减缓大脑衰老的关联在认知健康的世界贸易中心响应者中
Saren H Seeley1, Rachel Fremont1, Zoe Schreiber1
1Depression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Biological psychiatry global open science
|June 9, 2025
概括
世界贸易中心 (WTC) 的反应者具有高度的弹性,与PTSD患者相比,他们的大脑衰老速度较慢. 这种弹性可能会防止认知能力下降,乐观等因素与更好的大脑衰老有关.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 公共卫生 公共卫生
背景情况:
- 世界贸易中心 (WTC) 应急人员面临重大创伤,但大多数人表现出心理性.
- 弹性可以缓冲与创伤后应激障碍 (PTSD) 相关的与年龄相关的认知变化.
- 这项研究研究了WTC响应者的大脑衰老,以了解弹性机制.
研究的目的:
- 为了检查心理弹性和WTC响应者的大脑衰老之间的关系.
- 为了确定弹性是否与减缓大脑衰老有关.
- 探索大脑衰老,心理因素和认知措施之间的联系.
主要方法:
- 来自97名WTC受访者的结构性MRI数据使用深度学习算法 (BrainStructureAges) 进行分析.
- 受访者被分为与WTC相关的PTSD,高度弹性和较低的WTC暴露组.
- 估计了大脑年龄,并与时间学年龄进行比较,以评估大脑衰老的加速或减速.
主要成果:
- 高度性响应者表现出脑衰老减缓,而PTSD组显示脑衰老加速.
- 在高度弹性和PTSD组之间观察到大脑衰老的显著差异 (p = .021).
- 较小的大脑衰老与弹性因素相关:情绪抑制较低,乐观度更高,语言学习更好.
结论:
- 认知健康的WTC反应者表现出与弹性和PTSD相关的脑衰老的独特模式.
- 心理性似乎与更健康的大脑衰老轨迹有关.
- 这些发现突显了创伤暴露人群中恢复力的神经生物学影响.
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