年龄,性别和症状依赖的总IgE和eosinophils的变化在亚topic患者:一个五年回顾性研究
Lei Zhao1, Yiting Wu1, Hui Zhu1
1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
过敏原检测对于过敏性疾病至关重要,即使总免疫球蛋白E (t-IgE) 和乙素水平正常. 这些生物标志物因年龄和性别而异,它们与过敏的相关性并不总是直接的.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- 临床诊断 临床诊断 临床诊断
背景情况:
- 总免疫球蛋白E (t-IgE) 和埃索因菲尔是过敏性疾病的关键生物标志物.
- 人口因素 (年龄,性别) 和临床症状可能会影响这些生物标志物.
- 需要进一步调查t-IgE,埃索诺菲尔和亚托皮性疾病之间的关系.
研究的目的:
- 在患有过敏症状的患者中,探索跨人口和临床参数的t-IgE和乙氨基基基水平的变化.
- 了解t-IgE,乙氨基基和诊断过敏之间的相关性.
- 为了确定患者子组,尽管有过敏状况,但可能呈现正常生物标志物水平.
主要方法:
- 对7654名患有过敏症状的患者进行了回顾性研究.
- 收集人口统计数据 (年龄,性别),临床症状和完整的血液样本.
- 与各种参数和过敏原检测结果相关的t-IgE和乙酸蛋白水平的分析.
主要成果:
- 在儿童中,t-IgE和氨基基基水平达到峰值,随着年龄的增长而下降,趋势相互反映.
- 女性始终表现出比男性更低的t-IgE和乙氨基酸水平.
- 患有呼吸道症状的患者≥12岁时,t-IgE和埃索诺菲尔升高最常见;然而,在显著一部分亚托皮病患者,特别是女性中,观察到正常水平.
结论:
- 年龄,性别和特定症状影响过敏患者的t-IgE和乙氨基基基水平.
- 正常的t-IgE和乙氨基基基水平并不排除过敏性疾病,需要进一步的过敏原测试来准确诊断和治疗.
- 特别注意的是年龄较大的人群,女性性别,皮肤/耳鼻腔症状和特定过敏原敏感性,即使生物标志物水平正常.
更多相关视频
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
07:10Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
Published on: April 21, 2019
相关概念视频
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Allergic Reactions
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
