卵巢癌中的非细菌性血栓性内心炎:系统性审查
Mahalia Huba1, Fahad Hussain2, Saimanoj Guntaka2
1Medical University of South Carolina, 268 Calhoun St, Charleston, SC 29425, USA.
Gynecologic oncology reports
|June 9, 2025
概括
非细菌性血栓内心炎 (NBTE) 是卵巢癌患者死亡的重要原因之一. 在患有血栓栓塞事件的卵巢癌患者中,早期怀疑NBTE对于及时诊断和管理至关重要.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 非细菌性血栓内心炎 (NBTE) 涉及心脏门上的无菌植被,通常与高凝血状态有关.
- NBTE是一种罕见的疾病 (发病率为0.9%-1.6%),经常与妇科恶性瘤,特别是卵巢癌有关.
研究的目的:
- 综合审查关于非细菌性血栓内心炎和卵巢癌之间的关联的文献.
- 了解NBTE和卵巢癌患者的临床表现,治疗和结果.
主要方法:
- 从数据库开始到2024年1月,在PubMed/MEDLINE上进行了系统的文献搜索.
- 纳入标准侧重于被诊断为NBTE和卵巢癌的患者;排除标准涉及未经证实的诊断.
- 使用混合方法分析测试评估了偏差风险.
主要成果:
- 该审查从14份病例报告中确定了15名患者,平均年龄为50.6岁.
- 在57%的病例中,卵巢癌,通常是III/IV阶段 (67%),在NBTE诊断之前. 常见的转移部位包括淋巴结和肝脏.
- 死亡率很高 (75%全因),NBTE主要影响 mitra ,导致器官梗塞,特别是在大脑和脏. 化疗与较低的死亡率有关 (40%) 与没有化疗 (100%) 相比.
结论:
- 非细菌性血栓内心炎是卵巢癌患者死亡率的关键,经常被忽视的因素.
- 在表现出血栓栓塞现象的卵巢癌患者中,对NBTE的高度临床怀疑是合理的.
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