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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
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通过二皮里米丁脱酶多态性测试优化光皮里米丁疗法.

Arunkumar Krishnan1

  • 1Department of Supportive Oncology, Atrium Health Levine Cancer, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com.

World journal of gastrointestinal oncology
|June 9, 2025
PubMed
概括

对二皮里米丁脱酶 (DPYD) 缺乏症的药物遗传学测试改善了皮里米丁 (FP) 癌症治疗的安全性. 需要进一步的研究来解决局限性问题,并将DPYD测试纳入临床实践,以获得更好的患者结果.

科学领域:

  • 在瘤学瘤学.
  • 药物遗传学 药物遗传学
  • 临床医学 临床医学

背景情况:

  • 甲胺 (FP) 在固体瘤治疗中至关重要,但在20%-30%的患者中引起严重的毒性.
  • 通过DPYD多态体识别的二皮里米丁脱酶 (DPYD) 缺乏是FP毒性的关键因素.
  • 对DPYD变异的药物遗传测试通过减少不良事件改善了FP治疗安全性.

研究的目的:

  • 评估DPYD多态度的患病率及其对意大利胃肠道癌症患者FP耐受性的影响.
  • 确定当前DPYD测试和FP耐受性研究的局限性.
  • 推提高DPYD测试和FP治疗方案的策略.

主要方法:

  • 在意大利胃肠道癌症患者中对DPYD多态和FP耐受性的回顾性分析.
  • 评估DPYD变体测试的一致性和考虑混因素.
  • 对DPYD测试和FP毒性现有文献的审查.

主要成果:

  • 该研究强调了DPYD测试对FP安全性的重要性,但指出其追溯设计和不一致的变种查的局限性.
  • 社会经济和混因素没有得到充分的解决,这限制了研究结果的概括性.
  • 确定需要更广泛的DPYD变种查和成本效益分析.
关键词:
二皮里米丁脱水酶.药物不良反应 药物不良反应毒性药物毒性 毒性药物毒性经济评估 经济评价光皮里米丁 (Fluoropyrimidine) 是一种酸的化合物.胃肠道的癌症 胃肠道的癌症基因检测是一种基因检测.多态形态的多态化

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结论:

  • 整合DPYD指导剂量和标准化治疗前遗传咨询对于改善FP治疗结果至关重要.
  • 需要有强有力的统计分析的前性研究来加强DPYD测试的临床证据.
  • 解决局限性和进行成本效益分析将支持DPYD测试的更广泛的临床实施.