上衣细胞淋巴瘤的食道参与呈现多重淋巴细胞多重症:一个单中心研究
Makoto Saito1, Yoshitaka Oda2, Hirokazu Sugino2
1Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan. ikyoku@aiiku-hp.or.jp.
World journal of gastrointestinal oncology
|June 9, 2025
概括
带有食道参与的地幔细胞淋巴瘤 (MCL),呈现为多发性淋巴状多重症 (MLP),表明巨大的瘤负担和不良预后. 生存率显著降低,突出显示了这种罕见表现的侵略性.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 血液学 血液学 血液学
背景情况:
- 膜细胞淋巴瘤 (MCL) 经常涉及胃肠道,通常是多发性淋巴状多重症 (MLP).
- 肠道参与MCL与MLP是罕见的,只有有限的综合性研究可用.
- 患有MLP的食道MCL的临床特征和预后仍然不太清楚.
研究的目的:
- 研究患有食道MLP的MCL患者的临床表现和结果.
- 确定与这种罕见的MCL表现相关的预后因素.
主要方法:
- 在2001年至2021年期间,对6名MCL患者进行了回顾性分析,这些患者有组织病理学确认的食道MLP.
- 评估临床特征,治疗方法和生存数据.
主要成果:
- 所有患者都表现出广泛的疾病,包括胃肠道,节点,骨髓和/或脏的参与.
- 化疗是主要的治疗方法;然而,结果很差.
- 平均存活时间不到2年,5年存活率约为30%.
结论:
- 作为MLP呈现的MCL中食道参与与相当大的瘤负担有关.
- 这种特定的呈现预示着预后不好,生存时间有限.
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