使用机器学习预测胃癌存活率:一个系统性审查
Hong-Niu Wang1,2, Jia-Hao An3, Fu-Qiang Wang1
1Department of Gastrointestinal Surgery, Changzhi People's Hospital, The Affiliated Hospital of Changzhi Medical College, Changzhi 046000, Shanxi Province, China.
World journal of gastrointestinal oncology
|June 9, 2025
概括
机器学习 (ML) 显示出预测胃癌存活率的前景,为个性化治疗提供了潜力. 需要进一步的研究,包括前性试验,以克服局限性并增强临床应用.
科学领域:
- 在瘤学瘤学.
- 医疗信息学 医疗信息学
- 计算生物学 计算生物学
背景情况:
- 胃癌 (GC) 的生存预测是具有挑战性的.
- 机器学习 (ML) 提供了潜力,但面临着可解释性和数据限制.
研究的目的:
- 评估用于GC生存预测的ML应用.
- 确定GC当前ML方法中的关键局限性.
主要方法:
- 从PubMed/Web of Science获得的16项研究 (2019年后) 的系统文献综述.
- 分析ML模型类型 (深度学习,随机森林,SVM,合集) 和数据集大小.
- 包括经过外部验证的研究.
主要成果:
- 在ML模型中,AUC达到0.669-0.980 (整体存活率),0.920-0.960 (癌症特异性) 和0.710-0.856 (无疾病).
- 在GC患者中展示了个性化治疗规划和风险分层的潜力.
结论:
- ML模型对GC生存预测有显著的前景.
- 挑战包括追溯数据的依赖性和缺乏可解释性.
- 建议包括前性试验和多维数据整合.
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