新的环和g-butyrolactone衍生物来自一个内生菌株的cophinforma mamane
Clara Litot1, Marieke Vansteelandt1, Sergio Ortiz1,2
1UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, Toulouse 31062, France.
ACS omega
|June 9, 2025
概括
从Bixa orellana发现了一种新的γ-butyrolactone和三个环类. 化合物2显示出有前途的抗莱什曼和细胞毒性活动.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 微生物学 微生物学
背景情况:
- 内生真菌,如Cophinforma mamane,是新型生物活性化合物的丰富来源.
- 比克萨·奥雷拉纳 (Bixa orellana) 是一种具有传统医药用途的植物,需要进行植物化学研究.
研究的目的:
- 从内生Cophinforma mamane菌株中分离和描述新的化学实体.
- 评估分离化合物的生物活性,以对抗婴儿莱什曼尼亚,癌细胞和细菌.
主要方法:
- 使用色谱技术分离化合物.
- 通过广泛的光谱分析 (NMR,MS) 和DP4+计算来阐明结构.
- 生物活性测定包括抗莱什曼,细胞毒性和抗菌评估.
主要成果:
- 确定了一种新的g-butyrolactone (2) 和三个新的环 (3-5),以及已知的化合物1.
- 化合物1和2表现出对莱什马尼亚婴儿黄蜂的中度抑制活性.
- 化合物2对Jurkat细胞表现出细胞毒性作用,以及对Enterococcus faecalis的弱抗菌活性.
结论:
- 来自Bixa orellana的内生菌Cophinforma mamane产生了新的γ-butyrolactone和cyclopentapeptide化合物.
- 化合物2是作为抗莱什曼和细胞毒剂进一步开发的有希望的候选物.
- 这项研究强调了内菌在药物发现中的潜力.
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