交感神经在老鼠介质周周血管脂肪组织中分布稀疏
William F Jackson1, Emma D Flood1, D Adam Lauver1
1Department of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, United States.
周血管脂肪组织 (PVAT) 具有有限的交感神经内置,主要沿着血管. 这表明间膜PVAT中对单个脂肪细胞的直接神经控制最小.
科学领域:
- 血管生物学 血管生物学
- 脂肪组织生物学 脂肪组织生物学
- 神经科学是一个神经科学.
背景情况:
- 周血管脂肪组织 (PVAT) 影响血管功能.
- 建议对PVAT的交感神经输入来调节这种效应.
- 交感神经系统对PVAT内化的程度尚未完全理解.
研究的目的:
- 为了研究大鼠介质PVAT的交感内置.
- 在对达尔盐敏感 (Dahl-SS) 的老鼠中检查PVAT,高血压的模型.
- 为了确定氨酸氧化酶 (TH) 阳性神经是否存在于介质PVAT中.
主要方法:
- 在中腔PVAT,动脉和小肠中进行全山免疫光染色.
- 针对氨酸氧酶 (TH) 和CD-31 (PECAM) 的抗体被使用.
- 对焦显微镜和图像分析量化了神经和血管的标记.
主要成果:
- 在Sprague-Dawley和Dahl-SS大鼠的中肠PVAT中发现了有限的TH-阳性神经内置.
- 大多数TH阳性神经在PVAT内的小血管沿线观察到.
- 强大的TH-阳性神经标记存在于介质阻力动脉上,与PVAT不同.
- CD-31标签证实了抗体透和血管存在.
结论:
- 中腔PVAT表现出TH阳性交感神经的稀疏内化.
- 单个PVAT脂肪细胞的交感神经控制似乎有限.
- 神经主要与PVAT内的血管有关,而不是脂肪细胞本身.
更多相关视频
12:29Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis
Published on: May 20, 2012
08:41Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
相关概念视频
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Sympathetic Division of the ANS
Originating in the thoracic and lumbar spinal cord segments, the preganglionic fibers of the sympathetic division exit the spinal cord through the white ramus communicans. They then enter the...
Sympathetic Pathways: Sympathetic Chain Ganglia
The postganglionic neurons of the sympathetic trunk...
Sympathetic Signaling
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Parasympathetic Division of the ANS
Peripheral Nervous System: Ganglia and Nerves
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports...
