患者报告的胃肠道干扰与系统性硬化症中的生活质量降低和残疾有关
Patrik Kéringer1, Katalin T Kovács1, Gabriella Nagy1
1Department of Rheumatology and Immunology, Medical School, University of Pécs, Pécs, Hungary.
Journal of scleroderma and related disorders
|June 9, 2025
概括
系统性硬化症中的胃肠道问题显著恶化了生活质量和残疾. 这些影响在疾病的早期就显而易见,并且无论持续时间如何,都会影响所有患者亚组.
科学领域:
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
- 生活质量研究 研究 生命质量研究
背景情况:
- 系统性硬化症 (SSc) 是一种慢性自身免疫性疾病,其特征是皮肤和内部器官纤维化.
- 胃肠道 (GI) 的参与在SSc中很常见,并且可以显著影响患者的福祉.
- 患者报告的结果测量 (PROM) 对于评估SSc对日常生活的影响至关重要.
研究的目的:
- 研究胃肠道干扰严重程度对系统性硬化症患者的生活质量和残疾的影响.
- 利用患者报告的结果测量 (PROM) 来量化这些影响.
主要方法:
- 收集了160名SSc患者的数据,包括临床特征和PROM.
- 胃肠道症状严重程度使用加利福尼亚大学洛杉矶硬质皮质临床试验联盟胃肠道2.0 (UCLA-GIT 2.0) 尺度进行评估,将患者分为无至轻度,中度和严重的组.
- 评估生活质量和残疾的PROMs与UCLA-GIT 2.0分数相比被分析,可靠性为1年的随访 (n=149).
主要成果:
- 中度至严重的胃肠道干扰 (UCLA-GIT 2.0分) 与更差的生活质量和增加残疾有显著的相关性.
- 这些相关性在有限和扩散的皮肤SSc亚组中一致,并且独立于疾病持续时间.
- 与没有轻微症状的患者相比,中度和严重的胃肠道症状患者报告的结果明显更差.
结论:
- 在全身性硬化症中,中度至重度的胃肠道干扰与生活质量下降和残疾增加密切相关.
- 这些负面影响在疾病的早期过程中表现出来,并且存在于不同的SSc亚型中.
- 这些发现强调了解决胃肠道症状的重要性,以改善SSc患者的整体福祉.
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