持久的手掌疹与teprotumumab治疗相关
Lance R He1, George A Villatoro, Michael T Yen
1Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, U.S.A.
在治疗甲状腺眼病的teprotumumab治疗期间和之后,患者出现了持续的双侧手掌皮疹. 这种以前未报告的副作用强调了需要对与这种治疗相关的不良事件进行警监测的必要性.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 皮肤病学 皮肤病学
背景情况:
- 甲状腺眼病 (TED) 是一种影响眼的自身免疫性疾病.
- 德普慕马布是一种类似胰岛素的生长因子1受体 (IGF-1R) 抑制剂,用于治疗TED.
- 与teprotumumab相关的不良事件越来越多地被记录在案.
研究的目的:
- 报告一种对teprotumumab的新奇和持续的皮肤不良反应.
- 强调在TED治疗期间监测和识别皮肤副作用的重要性.
主要方法:
- 一个77岁的男性患者的案例报告与积极的TED.
- 在teprotumumab治疗期间和之后观察皮肤学副作用.
- 临床评估皮疹的呈现和持久性.
主要成果:
- 患者在teprotumumab治疗期间出现了双边手掌皮疹.
- 即使在治疗过程完成后,手掌皮疹仍然存在.
- 手掌皮疹的这种特定模式和持续性以前没有在文献中描述过.
结论:
- 甲状腺眼病治疗teprotumumab可能与持续的手掌皮疹有关.
- 医疗保健提供者应在teprotumumab治疗期间和之后监测皮肤不良事件.
- 对潜在的长期副作用的认识对于患者管理至关重要.
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