在患有孤立REM睡眠行为障碍的患者中,血NfL,GFAP和pTau181
Claudio Liguori1,2, Mariana Fernandes1, Cinzia Zatti3
1Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
Sleep
|June 9, 2025
概括
异常REM睡眠行为障碍 (iRBD) 患者表现出血神经丝光链 (NfL) 和状纤维酸蛋白 (GFAP) 水平的升高,表明早期的神经退行. 这些血液生物标志物可能有助于跟踪iRBD的疾病进展.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 睡眠医学 睡眠医学
背景情况:
- 异常/孤立的REM睡眠行为障碍 (iRBD) 是神经退行性疾病,特别是α-synucleinopathies的前兆阶段.
- 基于血液的生物标志物提供了一种非侵入性方法来评估体内神经退行性变化.
- 与阿尔茨海默病 (AD) 相关的变化可以使用特定的血生物标志物进行评估.
研究的目的:
- 在iRBD患者中分析神经纤维光链 (NfL),质纤维酸蛋白 (GFAP) 和酸化-Tau 181 (pTau181) 的血水平.
- 为了比较iRBD患者,健康对照 (HC) 和AD患者之间的这些生物标志物水平.
- 调查血生物标志物与iRBD中的临床症状之间的关联.
主要方法:
- 横截面研究比较了44名iRBD患者,55名HC患者和28名AD患者.
- 对所有参与者进行了认知和运动评估.
- 使用SIMOA量化血NfL,GFAP和pTau181水平;统计分析包括ANCOVA和斯皮尔曼相关性.
主要成果:
- 与HC相比,iRBD患者的血NfL和GFAP水平显著更高.
- 在iRBD患者和HC患者之间,血pTau181水平相似.
- 与AD患者相比,iRBD患者的GFAP,NfL和pTau181水平较低;GFAP和NfL在iRBD中相关,但与临床症状无关.
结论:
- 在iRBD中血NfL和GFAP升高表明正在进行的神经退行过程,可能是神经元和质退行.
- 在iRBD中正常的pTau181水平表明,在这个阶段没有与阿尔茨海默氏症相关的神经退行.
- 作为追踪iRBD早期神经退行症的基于血液的标志物,NfL和GFAP显示出有前途的潜力,这需要进一步研究它们对表转化和指导干预的预测价值.
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