叶酸摄入量,MTHFR基因型和月经前症状
Tara Zeitoun1, Ahmed El-Sohemy1
1Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ONM5S 3H2, Canada.
The British journal of nutrition
|June 9, 2025
概括
低叶酸摄入量与特定的MTHFR基因变异相结合,增加了月经前抑郁症的风险. 充足的叶酸摄入量可以减轻患有PMS的女性这种遗传风险.
科学领域:
- 营养科学 营养科学
- 遗传学 遗传学是一种遗传学.
- 妇女健康 妇女健康
背景情况:
- 月经前症状 (PMS) 显著影响女性的幸福感.
- 包括叶酸在内的微量营养素与PMS严重程度有关,但它们的确切作用尚不清楚.
- 在PMS中,叶酸摄入量与MTHFR基因型之间的相互作用需要进一步研究.
研究的目的:
- 调查叶酸摄入量和MTHFR基因型与月经前症状之间的关联.
- 为了确定MTHFR基因型是否会改变叶酸摄入量和月经前抑郁症之间的关系.
主要方法:
- 678名年龄在20-29岁的女性报告了15个月经前症状.
- 饮食中的叶酸摄入量使用食物频率调查问卷进行评估.
- MTHFR C677T多态是基因型;逻辑回归分析了关联.
主要成果:
- MTHFR基因型与某些月经前症状有关.
- 低叶酸摄入量显示了MTHFR T等位基因与月经前抑郁症之间的附加关联.
- 具体来说,CT和TT基因型的人患抑郁症的几率较高,而低叶酸摄入量的人患抑郁症的几率较高.
- 在高叶酸摄入量妇女中,MTHFR基因型和抑郁症之间没有发现任何关联.
结论:
- 叶酸摄入量和MTHFR基因型相互作用,与月经前抑郁风险有关.
- 充足的叶酸消费可以抵消与某些MTHFR基因型相关的月经前抑郁症风险增加.
- 这些发现凸显了叶酸在治疗PMS,特别是月经前抑郁症方面的重要性.
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