通过补充托芬和N-乙谷氨酸补充,改善了被奶小猪养低蛋白饮食的肠道屏障功能和肠道微生物群
Shichao Liu1, Zhiyuan Tai2, Muzhi Li2
1Northeast Agricultural University, Harbin, 150030, China. LSC10251025@163.com.
Tropical animal health and production
|June 9, 2025
概括
补充低蛋白饮食的N-乙谷氨酸 (NAG) 和酸 (Trp) 显著改善了小猪的生长和肠道健康. 这种组合提高了断奶小猪的料效率,抗氧化能力和肠道屏障功能.
科学领域:
- 动物营养 动物营养
- 肠道微生物组研究研究
- 猪生理学 猪生理学
背景情况:
- 低蛋白饮食可能会对小猪生长和肠道健康产生负面影响.
- 酸 (NAG) 和酸 (Trp) 是可以减轻这些影响的关键营养素.
- 了解它们对肠道功能和微生物群的综合影响对于优化小猪的发育至关重要.
研究的目的:
- 评估用NAG和Trp补充低蛋白饮食对断奶小猪的生长,肠道功能和肠道微生物群的影响.
- 为了确定组合补充剂是否能增强抗压能力和整体健康.
- 研究营养补充,肠道健康和微生物组成之间的关系.
主要方法:
- 120只断奶小猪被分为五组:对照组,低蛋白 (LP),LP+NAG,LP+Trp和LP+NAG+Trp.
- 记录了增长绩效指标 (料摄入量,平均每日增益,料增益比率).
- 分析了肠道屏障功能 (密集结蛋白),抗氧化能力 (甲酸酶,谷氨过氧化酶),免疫球蛋白水平和肠道微生物群组成 (Actinomycetes丰富).
主要成果:
- 与对照组相比,LP+NAG+Trp组显示出优异的生长性能,包括较高的平均每日增益和料摄入量.
- 观察到增强的抗氧化能力,加酶和谷氨过氧化酶水平升高.
- 紧结蛋白 (ZO-1,claudin-1) 的表达增加表明肠道屏障得到加强.
- 在肠道微生物群中发现了更高的免疫球蛋白水平和更多的Actinomycetes,这表明免疫功能和肠道健康有所改善.
结论:
- 在低蛋白饮食中对NAG和Trp的联合补充有效地改善了断奶小猪的生长性能和料效率.
- 这种营养策略增强了肠道屏障的完整性和抗氧化能力.
- 观察到的肠道健康和免疫功能的改善可能与肠道微生物群中Actinomycetes的丰度增加有关.
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