在有差异化甲状腺癌患者的动态评估中帮助RhTSH
YanSong Lin1, Qiang Wen2, Wei Fu3
1Department of Nuclear Medicine, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China. linyansong1968@163.com.
概括
重组人甲状腺刺激激素 (ZGrhTSH) 有效地取代甲状腺激素撤销,用于评估差异化甲状腺癌 (DTC) 患者. 这种安全的替代品在检测放射性摄入量和血清铁血球蛋白水平方面表现出相似的有效性.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 临床试验 临床试验
背景情况:
- 差异化甲状腺癌 (DTC) 管理需要有效的动态评估.
- 甲状腺激素取消 (THW) 是一种标准方法,但可能会引起患者的不适.
- 新型重组型人类甲状腺刺激激素 (ZGrhTSH) 提供了一个潜在的替代方案.
研究的目的:
- 评估ZGrhTSH与THW在DTC患者动态评估中的疗效.
- 评估ZGrhTSH的安全性和免疫性.
- 确定ZGrhTSH和THW阶段之间的诊断全身扫描 (Dx-WBS) 和血清甲状腺蛋白 (Tg) 水平的一致性.
主要方法:
- 第三阶段,开放标签,多中心,在中国27个地点进行自我控制试验.
- 符合条件的DTC患者接受了完全或近乎完全的甲状腺切除术.
- 在ZGrhTSH刺激和THW阶段进行了Dx-WBS和血清Tg测量.
主要成果:
- 在评估放射性吸收和刺激Tg水平方面,ZGrhTSH的疗效与THW相当.
- ZGrhTSH和THW之间的扫描一致性为88.2%.
- 刺激Tg水平 (截止值1 ng/mL) 的一致性为90.4%,综合扫描和Tg一致性为93.6%.
- 在接受ZGrhTSH的患者中,轻度过渡性不良事件 (1或2级) 报告在10.9%的患者.
结论:
- 对于DTC患者的动态评估,ZGrhTSH与THW无差.
- ZGrhTSH是DTC评估的安全有效替代方案.
- 这种新型药物简化了DTC患者的动态评估过程.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
7.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.2K
Functions of Thyroid Hormones
5.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.0K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
501
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
501
The Thyroid Gland
6.7K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.7K


