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基于风湿性关节炎相关的间歇性肺病的基于计算机断层扫描的定量评分系统:用于检测渐进性纤维化病的回顾性诊断准确性研究

Mehmet Cihan Karacaoğlu^1,2, Betül Kızıldağ³, Burak Okyar⁴

¹Department of Radiology, Sütçü İmam University, Kahramanmaraş, Turkey. mcihankaracaoglu@hotmail.com.

Clinical rheumatology

|June 9, 2025

概括

定量CT分析有效地评估了类风湿性关节炎相关的间歇性肺病 (RA-ILD) 的严重程度. 方法1在区分有限的RA-ILD和广泛的RA-ILD方面表现出卓越的性能,与肺功能测试有很好的相关性.

科学领域:

放射学放射学是一门学科.
肺部病理学肺部病理学
类风湿病学类风湿病学

背景情况:

风湿性关节炎相关的间歇性肺病 (RA-ILD) 构成了重大的临床挑战.
对RA-ILD严重程度的客观评估受到半定量评分系统中观察者间和观察者内变化的阻碍.

研究的目的:

评估定量计算机断层扫描 (CT) 参数在评估RA-ILD的严重性方面的疗效.
将定量CT方法的性能与已建立的半定量评分系统和肺功能测试进行比较.

主要方法:

对RA患者CT图像和肺功能测试的回顾性分析.
应用两个定量CT分析方法 (方法1和方法2),使用不同的Hounsfield单位值.
相关性分析 (斯皮尔曼测试) 和ROC分析以评估诊断性能.

主要成果:

定量方法与关键的肺功能测试有显著的相关性,包括肺部对一氧化碳的扩散能力 (DLCO) 和总肺容量 (TLC).
与方法2相比,方法1 (ILD得分的AUC = 0.945,MCRD得分的0.911) 在区分有限和广泛的ILD方面表现出优异的表现.
这两种定量方法都在疾病严重程度分层方面表现出强大的诊断能力.

结论:

定量CT分析,特别是第1方法,为评估RA-ILD严重程度提供了可靠和可重复的方法.
这些用户独立的定量方法可以克服主观半定量评分的局限性.
定量CT对客观评估和早期发现RA-ILD进展具有前途.

关键词:

计算机辅助图像分析间歇性肺病间歇性肺病多检测器计算机断层扫描.肺功能测试试验肺功能测试试验类风湿性关节炎类风湿性关节炎类风湿性关节炎

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