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在非功能性上腺腺瘤,原发性阿尔多斯特隆症和基本高血压中对心脏功能障碍的比较分析

L Liu¹, X Li^2,3, W Ma^4,5

¹Department of Endocrinolgy, Peking University First Hospital, Xishiku Street, Beijing, 100034, Xicheng District, China.

Journal of endocrinological investigation

|June 9, 2025

概括

通过斑点跟踪心声学评估的全球纵向应变 (GLS) 揭示了非功能上腺瘤 (NF) 中的心脏功能障碍. 与基本高血压相比,NF患者表现出GLS受损,但比原发性阿尔多斯特隆症更好,表明了独特的心脏影响.

科学领域:

心脏病学心脏病学
内分泌学在内分泌学.
医疗成像医学成像

背景情况:

斑点跟踪回声心电图 (STE) 量化了左心室缩性表现,全球纵向应变 (GLS) 作为一个敏感的指标.
关于非功能性上腺腺瘤 (NF) 的GLS存在有限的数据,尽管与亚临床心血管功能障碍的潜在联系.
了解NF对心脏的影响对于比较早期重塑与原发性阿尔多斯特主义 (PA) 和基本高血压 (EH) 是至关重要的.

研究的目的:

评估GLS在检测NF患者早期心脏功能障碍方面的实用性.
为了比较NF,PA和EH患者的GLS.
在NF患者中评估心脏重塑.

主要方法:

追溯研究包括33名NF,33名PA和33名EH患者,根据性别和年龄进行匹配.
用于左心室GLS评估的斑点跟踪回声心电图 (STE).
使用IBM SPSS Statistics v29.0进行统计分析,其中P<0.050作为显著性值.

主要成果:

与EH (-22.17 ± 3.03%) 相比,GLS在NF患者中明显较低 (-20.63 ± 3.10%),但高于PA患者 (-18.55 ± 2.45%).
在NF患者中,高血压的患病率和缩血压的患病率最低.
在所有组中,GLS与皮质醇水平,葡萄糖耐受性受损和阿尔多-因比 (ARR) 相相关.

结论:

在NF患者中,心脏功能障碍在EH和PA之间处于中间位置.
非功能性上腺腺瘤对心脏健康有着微妙的影响.
GLS是评估NF心脏功能障碍的一个有价值的工具.

关键词:

上皮层腺瘤是什么全球纵向菌株 (GLS) 是指全球纵向菌株.主要的超阿尔多斯特主义.斑点跟踪回声心脏图谱 (echocardiography) 是一种跟踪斑点心脏图谱的方法.

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