揭露隐藏的风险:印度人口对他类药物治疗的横截面研究的药物遗传学见解
Shaik Mohammad Naushad1,2, Palani Kumar Palanichamy3, Jagadeesh Babu Sreemanthula3
1Department of Molecular Genetics and Genomics, Yoda Diagnostics Pvt Ltd., 6-3-862/A, Lal Bungalow, Ameerpet, Hyderabad, 500016, India. naushadsm@gmail.com.
Pharmacological reports : PR
|June 9, 2025
概括
药物遗传查显示,11%的人群有溶性载体有机阴离子载体家族成员1B1 (SLCO1B1) 功能减弱,7.4%的人群有SLCO1B1和ATP结合盒子子子家族G成员2 (ABCG2) 的组合缺陷. 这些发现凸显了需要调整他类药物剂量以预防肌肉病变的必要性.
科学领域:
- 药物基因组学 药物基因组学
- 药物新陈代谢 药物新陈代谢
- 临床药理学 临床药理学
背景情况:
- 由于失脂症的高发病率,在印度使用他类药物正在增加.
- 大约有18%的人口面临着因他类药物引起的肌肉病变的风险.
- 对于他类药物治疗的药物遗传决定因素,在人群层面进行查至关重要.
研究的目的:
- 查他类药物治疗的药物遗传学决定因素.
- 调查溶态载体有机离子载体家族成员1B1 (SLCO1B1) 和ATP结合盒子子子家族G成员2 (ABCG2) 变种的流行情况.
- 评估印度人口中他类药物诱导肌肉病的风险.
主要方法:
- 在2180名受试者身上进行了整体外基因组测序.
- 分析了变异数据以确定双型和表型.
- 评估了SLCO1B1和ABCG2变体对他类药物代谢的功能影响.
主要成果:
- 81%的受试者具有正常的SLCO1B1功能,而19%的受试者表现出功能下降或功能差.
- 81.46%的受试者具有正常的ABCG2功能,18.53%的受试者表现出功能下降或功能差.
- 结合SLCO1B1/ABCG2功能缺陷在7.4%的受试者中被观察到. 一种特定的SLCO1B1单元型 (C-C-C-A-A-A) 与高白血症的风险增加2.22倍有关.
结论:
- 11%的人口表现出SLCO1B1功能下降或差.
- 7.4%的人口在SLCO1B1和ABCG2.2中表现出功能下降或功能差.
- 调整每日他类药物剂量是必要的,以最大限度地降低他类药物诱导肌肉病变的风险.
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