在2型糖尿病中饮食模式,减少和血压:DASH4D随机临床试验
Scott J Pilla1,2,3, Hsin-Chieh Yeh1,2,4, Christine M Mitchell4
1Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
JAMA internal medicine
|June 9, 2025
概括
低的DASH4D饮食显著降低了2型糖尿病成年人的血压. 在这项研究中,减少是降血压效应的主要驱动因素.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 患有2型糖尿病和高血压的人面临心血管事件的风险增加.
- 关于饮食干预的研究有限,除了减肥之外,对于这种人口群体的血压管理.
研究的目的:
- 研究特定饮食模式和减少对被诊断为2型糖尿病的成年人血压水平的影响.
- 评估饮食方法以阻止糖尿病高血压 (DASH4D) 饮食与修饰一起的疗效.
主要方法:
- 一项随机四期交叉养研究 (DASH4D) 涉及2型糖尿病和高血压的成年人.
- 参与者每人吃了四种饮食5周:低的DASH4D,高的DASH4D,低的典型美国饮食和高的典型美国饮食.
- 体重保持不变,并为参与者提供所有食物.
主要成果:
- 与美国典型的高饮食相比,低的DASH4D饮食显著降低了4.6 mm Hg的静缩血压和2.3 mm Hg的静缩血压.
- 在每个饮食周期的前3周内观察到血压降低.
- 降低对血压的影响比DASH4D饮食本身的影响更为明显.
结论:
- DASH4D饮食,特别是与减少相结合时,有效地降低了2型糖尿病成年人的血压,其中许多人服用多种抗高血压药物.
- 减少是实现临床相关血压改善的关键因素.
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