活动旅行模式和事件痴呆症和大脑结构
Cunpeng Hou1,2, Yaqi Zhang1,2, Feiyang Zhao1,2
1Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
JAMA network open
|June 9, 2025
概括
像骑自行车一样,积极旅行显著降低了痴呆症的风险,并改善了大脑结构,特别是那些没有APOE ε4基因的人. 这项研究强调了骑自行车对大脑健康的好处.
科学领域:
- 神经科学与公共卫生
- 神经退行性疾病的流行病学.
- 身体活动和大脑健康
背景情况:
- 积极的旅行方式 (步行,骑自行车) 是体力活动的既定形式.
- 活跃旅行,痴呆风险和大脑结构之间的联系尚未得到充分理解.
- 遗传倾向可能会影响出行方式和痴呆症之间的关系.
研究的目的:
- 检查旅行方式与痴呆风险之间的长期关联.
- 为了研究旅行方式和大脑结构指标之间的关系.
- 为了确定遗传敏感性是否会改变旅行方式与痴呆症风险相关性.
主要方法:
- 使用英国生物库数据 (2006-2010) 进行的前性队列研究.
- 旅行方式分类:无活动,步行,混合步行,骑自行车,混合骑自行车.
- 评估了痴呆症发病率 (所有原因,YOD,LOD,AD) 和大脑结构 (MRI).
- 用于分析的Cox比例危险回归模型.
主要成果:
- 与不活动旅行相比,骑自行车/混合自行车与所有原因痴呆症 (HR 0.81),AD (HR 0.78),YOD (HR 0.60) 和LOD (HR 0.83) 的风险降低有关.
- 活动旅行与海马体积增加有关 (β0.05).
- 在所有原因的痴呆症和LOD中观察到旅行方式和APOE ε4载体状态之间的显著相互作用,而骑自行车的非载体的风险较低.
结论:
- 积极旅行,特别是骑自行车,与痴呆症风险降低和大脑结构改善有关.
- 在没有APOE ε4遗传风险因子的人群中,骑自行车对痴呆的保护作用可能更为明显.
- 促进骑自行车等活跃的旅行方式可能是预防痴呆症和保持大脑健康的策略.
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