相关实验视频

Updated: Sep 19, 2025

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

Published on: October 28, 2019

基于MOFs的纳米诱导器使协同光免疫疗法的过度自成为可能

Weier Bao¹, Jiaqi Meng¹, Tang Li¹

¹School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.

Small (Weinheim an der Bergstrasse, Germany)

|June 9, 2025

概括

一个新的纳米诱导器 (UCBH) 使用近红外光触发过度的自和免疫细胞死亡,用于癌症治疗. 这种方法有效地抑制了瘤的生长,显示了精确光免疫疗法的前景.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

开发有针对性的癌症疗法对于改善患者的治疗结果至关重要.
纳米材料为药物输送和治疗应用提供独特的特性.
光热和光动力疗法是瘤学的新兴策略.

研究的目的:

开发一个核心纳米诱导器 (UCBH) 用于近红外 (NIR) 光触发的免疫细胞死亡.
通过释放氧化 (NO) 和铜离子 (Cu+) 来研究UCHB诱导的过度自的机制.
在瘤异种移植模型中评估UCBH的体内治疗疗效.

主要方法:

一个核心纳米诱导器的合成,其中包括一个上转化纳米粒子 (UCNP) 核心和一个含有氧化 (NO) 前体 (BNN6) 的金属有机框架 (MOF) .
尼尔射线照射以诱导Cu (II) -到-Cu (I) 光还原,BNN6激活,并释放Cu+,1,3,5-二甲酸盐 (BTC) 和NO.
通过Cu+和NO介导途径评估自的启动和维持,以及BTC在放大自级联中的作用.
在NIR照射后的细胞衍生瘤异种移植模型中体内评估UCBH的瘤生长抑制.

主要成果:

通过NIR光触发的过度自,UCBH成功地引起了免疫细胞死亡.
红外线光激活BNN6并释放Cu+,BTC和NO,启动和维持自.
+激活ULK1,启动自,而NO诱导线粒体损伤,为持续的自提供基质.
通过激活ULK1和损害线粒体代谢,BTC可以增强自.
在体内初步研究表明,在NIR照射时,UCBH显著抑制了瘤生长.

结论:

UCBH是一种有效的纳米诱导剂,可通过过度的自引发免疫细胞死亡.
开发的平台显示了精确,时空控制的协同光免疫疗法的潜力.
这项研究强调了结合纳米技术,光化学和自调节来治疗癌症的治疗潜力.

关键词:

过度的自性过度的自性免疫性细胞死亡免疫性细胞死亡金属有机框架的框架.摄影控制释放的释放.照相免疫疗法是一种照相免疫疗法.

更多相关视频

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

相关概念视频

Autophagic Cell Death

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...

Autophagy

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...