调节细菌与宿主之间的相互作用,通过对细菌表面的共价结合进行疾病干预
Mian Chen1,2, Jinyao Liu1
1Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Accounts of chemical research
|June 9, 2025
概括
表面共价结合 (SCC) 修改了细菌在体内有针对性的相互作用,通过增强宿主免疫调节和新陈代谢提供了新的疾病干预策略. 这种方法精确地调整细菌的行为,用于治疗应用.
科学领域:
- 生物材料科学 生物材料科学
- 合成生物学 合成生物学
- 微生物学 微生物学
背景情况:
- 细菌与宿主环境的相互作用对于免疫调节和新陈代谢至关重要.
- 目前调节这些相互作用的方法是有限的,人们对它们的理解也很差.
- 细菌表面修饰为治疗干预提供了一个有希望的途径.
研究的目的:
- 通过表面共价结合 (SCC) 来调节细菌与宿主相互作用的进展.
- 探索SCC作为一种开发新型疾病干预策略的方法.
- 突出SCC在工程细菌中的潜力,用于特定的体内功能.
主要方法:
- 在细菌表面上利用反应组介导的共价结合 (例如,乙化,化,醇-迈克尔添加,多巴胺聚合).
- 将小分子,宏分子和纳米粒子附着在细菌上,而不会影响它们的生命力.
- 具有增强准,殖民和微环境改造能力的工程细菌.
主要成果:
- 证明了SCC能够稳定地将功能组件连接到具有高特异性的细菌的能力.
- 展示了改造后的细菌,改善了细胞和组织的相互作用,以实现有针对性的输送.
- 突出了在治疗炎症性肠道疾病,瘤和受感染的伤口方面的成功应用.
结论:
- 表面共价结合为工程细菌提供了一个多功能平台,具有量身定制的体内功能.
- 由SCC介导的细菌修饰为疾病干预提供了显著的潜力.
- 需要进一步的研究和临床翻译才能充分实现工程细菌的治疗承诺.
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